| Descripteur français | Protéines associées à la multirésistance aux médicaments |
| Descripteur américain | Multidrug Resistance-Associated Proteins |
| Terme(s) français | Protéines associées à la multirésistance aux médicaments / |
| Terme(s) américain(s) | Multidrug Resistance-Associated Proteins / |
| Scope Note | A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins. |
| Code(s) d'arborescence | D12.776.157.530.100.304 / D12.776.157.530.450.074.500.500.500 / D12.776.543.585.100.304 / D12.776.543.585.450.074.500.500.500 / |
| Qualificatifs autorisés français | isolement et purification / immunologie / pharmacocinétique / biosynthèse / physiologie / usage thérapeutique / agonistes / sang / liquide cérébrospinal / synthèse chimique / déficit / composition chimique / effets des médicaments et des substances chimiques / urine / effets des radiations / histoire / analyse / classification / économie / génétique / pharmacologie / normes / administration et posologie / antagonistes et inhibiteurs / ressources et distribution / ultrastructure / intoxication / effets indésirables / toxicité / métabolisme / |
| Qualificatifs autorisés américains | isolation & purification / immunology / pharmacokinetics / biosynthesis / physiology / therapeutic use / agonists / blood / cerebrospinal fluid / chemical synthesis / deficiency / chemistry / drug effects / urine / radiation effects / history / analysis / classification / economics / genetics / pharmacology / standards / administration & dosage / antagonists & inhibitors / supply & distribution / ultrastructure / poisoning / adverse effects / toxicity / metabolism / |
| Qualificatifs autorisés abrégés | IP / IM / PK / BI / PH / TU / AG / BL / CF / CS / DF / CH / DE / UR / RE / HI / AN / CL / EC / GE / PD / ST / AD / AI / SD / UL / PO / AE / TO / ME / |
| Indexation antérieure | P-Glycoprotein (1987-2001) / |
| Identifiant | D027425 |
| Date d'ajout et note historique | 2002; use MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS (NM) 1994-2001; for MOAT PROTEIN & MULTISPECIFIC ORGANIC ANION TRANSPORTER use ANION TRANSPORT PROTEINS 1995-2001 |
| Voir aussi le(s) descripteur(s) français | |
| Voir aussi le(s) descripteur(s) américain(s) | Drug Resistance, Multiple / ATP Binding Cassette Transporter, Subfamily B / |