| Descripteur français | Sous-famille B de transporteurs à cassette liant l'ATP |
| Descripteur américain | ATP Binding Cassette Transporter, Subfamily B |
| Terme(s) français | Sous-famille B de transporteurs à cassette liant l'ATP / |
| Terme(s) américain(s) | ATP Binding Cassette Transporter, Subfamily B / |
| Scope Note | A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology. |
| Code(s) d'arborescence | D12.776.157.530.100.075 / D12.776.157.530.450.074.500.500.250 / D12.776.395.550.020.400 / D12.776.543.550.192.400 / D12.776.543.585.100.200 / D12.776.543.585.450.074.500.500.250 / |
| Qualificatifs autorisés français | isolement et purification / immunologie / pharmacocinétique / biosynthèse / physiologie / usage thérapeutique / agonistes / sang / liquide cérébrospinal / synthèse chimique / déficit / composition chimique / effets des médicaments et des substances chimiques / urine / effets des radiations / histoire / analyse / classification / économie / génétique / pharmacologie / normes / administration et posologie / antagonistes et inhibiteurs / ressources et distribution / ultrastructure / intoxication / effets indésirables / toxicité / métabolisme / |
| Qualificatifs autorisés américains | isolation & purification / immunology / pharmacokinetics / biosynthesis / physiology / therapeutic use / agonists / blood / cerebrospinal fluid / chemical synthesis / deficiency / chemistry / drug effects / urine / radiation effects / history / analysis / classification / economics / genetics / pharmacology / standards / administration & dosage / antagonists & inhibitors / supply & distribution / ultrastructure / poisoning / adverse effects / toxicity / metabolism / |
| Qualificatifs autorisés abrégés | IP / IM / PK / BI / PH / TU / AG / BL / CF / CS / DF / CH / DE / UR / RE / HI / AN / CL / EC / GE / PD / ST / AD / AI / SD / UL / PO / AE / TO / ME / |
| Annotation | note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 is also available |
| Indexation antérieure | Glycoproteins (1980-1987) / Membrane Glycoproteins (1989-1994) / Membrane Proteins (1980-1988) / |
| Identifiant | D018435 |
| Date d'ajout et note historique | 2019 (1999); use P-GLYCOPROTEIN 1995-1998 |
| Voir aussi le(s) descripteur(s) français | |
| Voir aussi le(s) descripteur(s) américain(s) | Drug Resistance, Multiple / Genes, MDR / Rhodamine 123 / Multidrug Resistance-Associated Proteins / |