Descripteur français	Souris knockout
Descripteur américain	Mice, Knockout
Terme(s) français	Souris knockout /
Terme(s) américain(s)	Mice, Knockout /
Scope Note	Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Code(s) d'arborescence	B01.050.050.136.500.500 / B01.050.150.900.649.313.992.635.505.500.550.455 / B01.050.150.900.649.313.992.635.505.500.800.500 /
Qualificatifs autorisés français	malformations / anatomie et histologie / sang / liquide cérébrospinal / classification / embryologie / génétique / croissance et développement / immunologie / traumatismes / métabolisme / microbiologie / parasitologie / physiologie / psychologie / chirurgie / urine / virologie /
Qualificatifs autorisés américains	abnormalities / anatomy & histology / blood / cerebrospinal fluid / classification / embryology / genetics / growth & development / immunology / injuries / metabolism / microbiology / parasitology / physiology / psychology / surgery / urine / virology /
Qualificatifs autorisés abrégés	AB / AH / BL / CF / CL / EM / GE / GD / IM / IN / ME / MI / PS / PH / PX / SU / UR / VI /
Annotation	NIM no qualif when exper animal; do not forget also to check MICE
Indexation antérieure	Mice (1992-1993) /
Identifiant	D018345
Date d'ajout et note historique	94
Voir aussi le(s) descripteur(s) français
Voir aussi le(s) descripteur(s) américain(s)	Gene Knockout Techniques /