Descripteur français	Altération de l'ADN
Descripteur américain	DNA Damage
Terme(s) français	Altération de l'ADN / Stress génotoxique /
Terme(s) américain(s)	DNA Damage / Genotoxic Stress / Genotoxic Stresses / Stresses, Genotoxic / Stress, Genotoxic /
Scope Note	Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Scope Note	DNA DAMAGE in vivo.
Code(s) d'arborescence	G05.200 /
Qualificatifs autorisés français	effets des médicaments et des substances chimiques / génétique / immunologie / physiologie / effets des radiations / éthique /
Qualificatifs autorisés américains	drug effects / genetics / immunology / physiology / radiation effects / ethics /
Qualificatifs autorisés abrégés	DE / GE / IM / PH / RE / ES /
Annotation	do not use /drug eff & /rad eff for DNA damage induced by drugs or radiation; do not confuse with DNA FRAGMENTATION: see note there
Indexation antérieure	DNA (1966-1986) / DNA Repair (1971-1986) / DNA Replication (1968-1986) /
Identifiant	D004249
Date d'ajout et note historique	87
Voir aussi le(s) descripteur(s) français
Voir aussi le(s) descripteur(s) américain(s)	Mutation / Pyrimidine Dimers /