Descripteur français	Agents alcoylants
Descripteur américain	Alkylating Agents
Terme(s) français	Agents alcoylants /
Terme(s) américain(s)	Alkylating Agents /
Scope Note	Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
Code(s) d'arborescence	D27.505.519.124 / D27.888.569.035 /
Qualificatifs autorisés français	isolement et purification / immunologie / pharmacocinétique / usage thérapeutique / sang / liquide cérébrospinal / synthèse chimique / composition chimique / urine / effets des radiations / histoire / analyse / classification / économie / pharmacologie / normes / administration et posologie / ressources et distribution / intoxication / effets indésirables / toxicité / métabolisme /
Qualificatifs autorisés américains	isolation & purification / immunology / pharmacokinetics / therapeutic use / blood / cerebrospinal fluid / chemical synthesis / chemistry / urine / radiation effects / history / analysis / classification / economics / pharmacology / standards / administration & dosage / supply & distribution / poisoning / adverse effects / toxicity / metabolism /
Qualificatifs autorisés abrégés	IP / IM / PK / TU / BL / CF / CS / CH / UR / RE / HI / AN / CL / EC / PD / ST / AD / SD / PO / AE / TO / ME /
Identifiant	D000477
Date d'ajout et note historique	66(64)